Synthesis of α-enaminones from cyclic ketones and anilines using oxoammonium salt as an oxygen transfer reagent

A convenient and straightforward transformation of cyclic ketones with anilines at room temperature has been developed using oxoammonium salt TEMPO + PF 6 − as an oxidant. This method enabled the synthesis of a broad range of α-enaminones. The 18 O-labeling experiment demonstrated that oxoammonium salt served as the oxygen transfer reagent. A convenient synthesis of α-enaminones from cyclic ketones with anilines at room temperature via an oxygen-atom-transfer pathway of oxoammonium salt.