Bi(OTf)(3)-catalysed regioselective arylation of Morita-Baylis-Hillman type allylic electrophiles

Bi(OTf)(3)-catalysed regioselective arylation of Morita-Baylis-Hillman type allylic electrophiles

The Friedel-Crafts reaction of a wide variety of arenes and heteroarenes was accomplished, in good to excellent yields (50-98%) and with high alpha -regioselectivity, using Morita-Baylis-Hillman acetates. Functionalized conjugated enones were obtained under Bi(OTf)(3) catalysis (10 mol%) in dichloro...

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Veröffentlicht in:Tetrahedron letters 2020-04, Vol.61 (15), Article 151758
Hauptverfasser: Omrani, Assia, Rezgui, Farhat, Dunach, Elisabet, Poulain-Martini, Sophie
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
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Zusammenfassung:The Friedel-Crafts reaction of a wide variety of arenes and heteroarenes was accomplished, in good to excellent yields (50-98%) and with high alpha -regioselectivity, using Morita-Baylis-Hillman acetates. Functionalized conjugated enones were obtained under Bi(OTf)(3) catalysis (10 mol%) in dichloroethane (DCE) at 50 degrees C. (C) 2020 Elsevier Ltd. All rights reserved.
ISSN:0040-4039
DOI:10.1016/j.tetlet.2020.151758