Study on the A(3)-coupling reaction catalyzed by readily available copper-containing minerals. Synthesis of propargylamines

Study on the A(3)-coupling reaction catalyzed by readily available copper-containing minerals. Synthesis of propargylamines

The highly atom efficient three-component reaction of aldehydes, secondary amines and acetylenes to form propargylamines (A(3)-coupling) has been studied with twelve readily available copper-containing minerals. It was found that the reaction could easily be performed in the presence of malachite, b...

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Veröffentlicht in:Tetrahedron letters 2020-03, Vol.61 (10), Article 151544
Hauptverfasser: Milen, Matyas, Gyorke, Gabor, Dancso, Andras, Volk, Balazs
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
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Zusammenfassung:The highly atom efficient three-component reaction of aldehydes, secondary amines and acetylenes to form propargylamines (A(3)-coupling) has been studied with twelve readily available copper-containing minerals. It was found that the reaction could easily be performed in the presence of malachite, brochantite, chrysocolla and azurite in toluene at reflux. The desired products were obtained in good to excellent yields. (C) 2019 Elsevier Ltd. All rights reserved.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2019.151544