Size-Transformable Hyaluronan Stacked Self-Assembling Peptide Nanoparticles for Improved Transcellular Tumor Penetration and Photo–Chemo Combination Therapy

Size-transformable nanomedicine has the potential to overcome systemic and local barriers, leading to efficient accumulation and penetration throughout the tumor tissue. However, the design of this type of nanomedicine was seldom based on active targeting and intracellular size transformation. Here,...

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Veröffentlicht in:	ACS nano 2020-02, Vol.14 (2), p.1958-1970
Hauptverfasser:	Cong, Zhaoqing, Zhang, Lu, Ma, Si-Qi, Lam, Kit S, Yang, Fei-Fei, Liao, Yong-Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - pharmacology Cell Line, Tumor Cell Survival Chemistry Chemistry, Multidisciplinary Chemistry, Physical Combined Modality Therapy Disease Models, Animal Dopamine - chemistry Female Folic Acid - chemistry Hyaluronic Acid - chemistry Indocyanine Green - administration & dosage Indocyanine Green - chemistry Injections, Intravenous Irinotecan - administration & dosage Irinotecan - chemistry Irinotecan - pharmacology Male Materials Science Materials Science, Multidisciplinary Melanoma, Experimental - diagnostic imaging Melanoma, Experimental - therapy Mice Mice, Inbred C57BL Nanoparticles - chemistry Nanoscience & Nanotechnology Optical Imaging Particle Size Peptides - chemical synthesis Peptides - chemistry Physical Sciences Rats Rats, Wistar Science & Technology Science & Technology - Other Topics Surface Properties Technology
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Zusammenfassung:	Size-transformable nanomedicine has the potential to overcome systemic and local barriers, leading to efficient accumulation and penetration throughout the tumor tissue. However, the design of this type of nanomedicine was seldom based on active targeting and intracellular size transformation. Here, we report an intracellular size-transformable nanosystem, in which small and positively charged nanoparticles (
ISSN:	1936-0851 1936-086X
DOI:	10.1021/acsnano.9b08434