Involvement of medial prefrontal cortex NMDA and AMPA/kainate glutamate receptors in social recognition memory consolidation

•Social recognition memory (SRM) consolidation engages the mPFC.•The blockade of NMDA receptors in the mPFC impaired SRM consolidation.•The blockade of AMPA/kainate receptors in the mPFC impaired SRM consolidation. Social recognition memory (SRM) enables the distinction between familiar and strange...

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Veröffentlicht in:Neurobiology of learning and memory 2020-02, Vol.168, p.107153-107153, Article 107153
Hauptverfasser: Marcondes, Lucas Aschidamini, Nachtigall, Eduarda Godfried, Zanluchi, André, de Carvalho Myskiw, Jociane, Izquierdo, Ivan, Furini, Cristiane Regina Guerino
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Sprache:eng
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Zusammenfassung:•Social recognition memory (SRM) consolidation engages the mPFC.•The blockade of NMDA receptors in the mPFC impaired SRM consolidation.•The blockade of AMPA/kainate receptors in the mPFC impaired SRM consolidation. Social recognition memory (SRM) enables the distinction between familiar and strange conspecifics, a fundamental ability for sociable species, such as rodents and humans. There is mounting evidence that the medial prefrontal cortex plays a prominent role both in shaping social behavior and in recognition memory. Glutamate is the major excitatory neurotransmitter in the brain, and activity of its ionotropic receptors is known to mediate both synaptic plasticity and consolidation of various types of memories. However, whether these receptors are required in the medial prefrontal cortex (mPFC) for SRM consolidation remains elusive. To address this issue, we submitted rats to a social discrimination paradigm, administered infusions of NMDA- and AMPA/kainate-receptors antagonists into the prelimbic (PrL) subdivision of the mPFC at different post-encoding time points and evaluated long-term memory retention twenty-four hours later. We found that blocking NMDA receptors immediately after the sample phase, but not 3 h later, impaired SRM consolidation, whereas the blockade of AMPA/kainate receptors immediately and 3 h, but not 6 h after the sample phase, prevented long-term memory consolidation. These results highlight the importance of the mPFC in social cognition and may contribute towards the understanding of the dysfunctional social information processing that underlies multiple neuropsychiatric disorders.
ISSN:1074-7427
1095-9564
DOI:10.1016/j.nlm.2019.107153