Studies towards the Total Synthesis of Kadcotrione B

Studies towards the Total Synthesis of Kadcotrione B

Abstract A convergent and efficient approach towards the total synthesis of Kadcotrione B is described. For this purpose, the syntheses of two fragments, 6/6/5-fused tricyclic ring and C-9 side chain, were accomplished. The salient features of these syntheses are the utilization of aldol condensatio...

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Veröffentlicht in:Synthesis (Stuttgart) 2020-03, Vol.52 (5), p.735-743
Hauptverfasser: Reddy, Julakanti Satyanarayana, Gangababu, Marri, Manimala, Patel, Rammohan, Aluru, Yadav, Jillu Singh
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
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Zusammenfassung:Abstract A convergent and efficient approach towards the total synthesis of Kadcotrione B is described. For this purpose, the syntheses of two fragments, 6/6/5-fused tricyclic ring and C-9 side chain, were accomplished. The salient features of these syntheses are the utilization of aldol condensation, Evans aldol reaction, Horner–Wadsworth–Emmons olefination, Michael addition, Robinson annulation, and Wacker oxidation.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-0039-1691494