Non-motor Symptoms in Parkinson’s Disease Patients with Parkin Mutations: More Depression and Less Executive Dysfunction

The purpose of this study was to identify differences between genetically undefined (GU) early-onset Parkinson’s disease (EOPD) patients and carriers of Parkin mutations on non-motor symptoms (NMSs). EOPD patients ( N  = 261) underwent targeted sequencing of Parkinson’s disease (PD) related genes. A...

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Veröffentlicht in:Journal of molecular neuroscience 2020-02, Vol.70 (2), p.246-253
Hauptverfasser: Song, Jie, Shen, Bo, Yang, Yu-Jie, Liu, Feng-tao, Zhao, Jue, Tang, Yi-Lin, Chen, Chen, Ding, Zheng-Tong, An, Yu, Wu, Jian-Jun, Sun, Yi-Min, Wang, Jian
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Sprache:eng
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Zusammenfassung:The purpose of this study was to identify differences between genetically undefined (GU) early-onset Parkinson’s disease (EOPD) patients and carriers of Parkin mutations on non-motor symptoms (NMSs). EOPD patients ( N  = 261) underwent targeted sequencing of Parkinson’s disease (PD) related genes. Among them, 53 cases carried homozygous or compound heterozygous Parkin mutations ( Parkin group) while 208 did not carry known causative PD mutations or risk factors of GBA or Parkin heterozygous mutations (GU group). NMSs were evaluated by face-to-face interviews, self-completed questionnaires and results on a neuropsychological battery. Linear regression and logistic regression models were applied to assess the predictors of NMSs. Parkin patients had younger ages of onset (AOO) ( p  
ISSN:0895-8696
1559-1166
DOI:10.1007/s12031-019-01444-3