Non-motor Symptoms in Parkinson’s Disease Patients with Parkin Mutations: More Depression and Less Executive Dysfunction
The purpose of this study was to identify differences between genetically undefined (GU) early-onset Parkinson’s disease (EOPD) patients and carriers of Parkin mutations on non-motor symptoms (NMSs). EOPD patients ( N = 261) underwent targeted sequencing of Parkinson’s disease (PD) related genes. A...
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Veröffentlicht in: | Journal of molecular neuroscience 2020-02, Vol.70 (2), p.246-253 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | The purpose of this study was to identify differences between genetically undefined (GU) early-onset Parkinson’s disease (EOPD) patients and carriers of
Parkin
mutations on non-motor symptoms (NMSs). EOPD patients (
N
= 261) underwent targeted sequencing of Parkinson’s disease (PD) related genes. Among them, 53 cases carried homozygous or compound heterozygous
Parkin
mutations (
Parkin
group) while 208 did not carry known causative PD mutations or risk factors of
GBA
or
Parkin
heterozygous mutations (GU group). NMSs were evaluated by face-to-face interviews, self-completed questionnaires and results on a neuropsychological battery. Linear regression and logistic regression models were applied to assess the predictors of NMSs.
Parkin
patients had younger ages of onset (AOO) (
p
|
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ISSN: | 0895-8696 1559-1166 |
DOI: | 10.1007/s12031-019-01444-3 |