Orodispersible films containing ball milled aripiprazole-poloxamer®407 solid dispersions

Orodispersible films containing ball milled aripiprazole-poloxamer®407 solid dispersions

[Display omitted] This research aimed at developing ODFs containing an antipsychotic drug – aripiprazole (ARP). ARP, as a BCS II class molecule, requires enhancing its water solubility prior to formulating. Therefore, a solid dispersion of ARP – Poloxamer® 407 was prepared by ball milling, then inco...

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Veröffentlicht in:International journal of pharmaceutics 2020-02, Vol.575, p.118955-118955, Article 118955
Hauptverfasser: Łyszczarz, Ewelina, Hofmanová, Justyna, Szafraniec-Szczęsny, Joanna, Jachowicz, Renata
Format: Artikel
Sprache:eng
Schlagworte:
Aripiprazole
Ball milling
Disintegration time
Life Sciences & Biomedicine
Orodispersible films
Pharmacology & Pharmacy
Poloxamer®407
Science & Technology
Tribology
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Zusammenfassung:[Display omitted] This research aimed at developing ODFs containing an antipsychotic drug – aripiprazole (ARP). ARP, as a BCS II class molecule, requires enhancing its water solubility prior to formulating. Therefore, a solid dispersion of ARP – Poloxamer® 407 was prepared by ball milling, then incorporated into the films. It was found that co-processing led to an over 100-fold increase in drug solubility in comparison with pure drug. Moreover, ODFs with solid dispersion showed faster drug release (>95% below 15 min) and disintegration (
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2019.118955