The basic machineries for mitochondrial protein quality control

Mitochondria play pivotal roles in cellular energy metabolism, the synthesis of essential biomolecules and the regulation of cell death and aging. The proper folding, unfolding and degradation of the many proteins active within mitochondria is surveyed by the mitochondrial quality control machinerie...

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Veröffentlicht in:	Mitochondrion 2020-01, Vol.50, p.121-131
Hauptverfasser:	Vazquez-Calvo, Carmela, Suhm, Tamara, Büttner, Sabrina, Ott, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggregates Cell Biology Chaperones Genetics & Heredity Humans Life Sciences & Biomedicine Mitochondria Mitochondria - metabolism Mitochondrial Proteins - genetics Mitochondrial Proteins - metabolism Mitophagy Proteases Protein Biosynthesis - physiology Protein Folding Proteolysis Proteostasis Quality control Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Science & Technology
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Beschreibung
Zusammenfassung:	Mitochondria play pivotal roles in cellular energy metabolism, the synthesis of essential biomolecules and the regulation of cell death and aging. The proper folding, unfolding and degradation of the many proteins active within mitochondria is surveyed by the mitochondrial quality control machineries. Here, we describe the principal components of the mitochondrial quality control system and recent developments in the elucidation of the molecular mechanisms maintaining a functional mitochondrial proteome.
ISSN:	1567-7249 1872-8278 1872-8278
DOI:	10.1016/j.mito.2019.10.003