Synthesis and Antiproliferative Evaluation of 5′‐Arylchalcogenyl‐3‐(phenylselanyl‐triazoyl)‐thymidine

This article discloses the synthesis and biological in vitro activity of a novel class of compounds derived from 5′‐arylchalcogenyl‐3‐(phenylselanyl‐triazoyl)‐thymidine as antitumor agents in the 5637 bladder carcinoma. The synthesis of the new molecules obtained good yields and proved to be efficient. The antitumor biological property, which was presented by a series of these unpublished compounds, demonstrates the importance of the presence of the nucleoside portion and the chalcogenium atom in the molecule. The preparation of a new class of bis‐organochalcogenides based on AZT nucleoside is reported. The compounds were prepared in a modular design and tested against 5637 bladder carcinoma cells. All compounds showed prominent activity against this strain, with tellurium showing higher effectiveness.