Assessing the viability of Soluplus® self-assembled nanocolloids for sustained delivery of highly hydrophobic lapatinib (anticancer agent): Optimisation and in-vitro characterisation

Assessing the viability of Soluplus® self-assembled nanocolloids for sustained delivery of highly hydrophobic lapatinib (anticancer agent): Optimisation and in-vitro characterisation

[Display omitted] •Nanocolloidal micelles (LP-PMs) were prepared to deliver hydrophobic drug, lapatinib.•Addition of Pluronic® F127 reduces the critical micelle concentration of Soluplus®.•Nanosize (

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Veröffentlicht in:Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2020-01, Vol.185, p.110611-110611, Article 110611
Hauptverfasser: Bonde, Gunjan Vasant, Ajmal, Gufran, Yadav, Sarita Kumari, Mittal, Pooja, Singh, Juhi, Bakde, Bharati V., Mishra, Brahmeshwar
Format: Artikel
Sprache:eng
Schlagworte:
Anti-cancer agent
Biophysics
Breast cancer
Chemistry
Chemistry, Physical
Dilution test
Life Sciences & Biomedicine
Materials Science
Materials Science, Biomaterials
Nanocarrier
Passive targeting
Physical Sciences
Pluronic® F127
Polymeric micelles
Science & Technology
Technology
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Beschreibung
Zusammenfassung:[Display omitted] •Nanocolloidal micelles (LP-PMs) were prepared to deliver hydrophobic drug, lapatinib.•Addition of Pluronic® F127 reduces the critical micelle concentration of Soluplus®.•Nanosize (
ISSN:0927-7765
1873-4367
DOI:10.1016/j.colsurfb.2019.110611