Comparison of the Response to Rituximab between Myelin Oligodendrocyte Glycoprotein and Aquaporin‐4 Antibody Diseases

Objective To compare response to rituximab (RTX) between adult patients positive for myelin oligodendrocyte glycoprotein (MOG) and aquaporin‐4 (AQP4) antibodies. Methods We prospectively studied adult patients with MOG or AQP4 antibodies who received RTX under an individualized dosing schedule adapt...

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Veröffentlicht in:	Annals of neurology 2020-02, Vol.87 (2), p.256-266
Hauptverfasser:	Durozard, Pierre, Rico, Audrey, Boutiere, Clémence, Maarouf, Adil, Lacroix, Romaric, Cointe, Sylvie, Fritz, Shirley, Brunet, Corinne, Pelletier, Jean, Marignier, Romain, Audoin, Bertrand
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Antibodies Aquaporin 4 Aquaporin 4 - immunology Aquaporins Autoantibodies - blood B-Lymphocyte Subsets - drug effects Biological effects Biomonitoring Cell Count Clinical Neurology Demyelinating Diseases - blood Demyelinating Diseases - drug therapy Demyelinating Diseases - immunology Depletion Female Glycoproteins Humans Immunoglobulins Immunologic Factors - therapeutic use Immunological memory Immunology Immunotherapy Life Sciences Life Sciences & Biomedicine Lymphocytes Lymphocytes B Male Memory cells Middle Aged Monoclonal antibodies Myelin Myelin-Oligodendrocyte Glycoprotein - immunology Neurosciences Neurosciences & Neurology Oligodendrocyte-myelin glycoprotein Peripheral blood Rituximab Rituximab - therapeutic use Schedules Science & Technology Treatment Outcome Young Adult
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Zusammenfassung:	Objective To compare response to rituximab (RTX) between adult patients positive for myelin oligodendrocyte glycoprotein (MOG) and aquaporin‐4 (AQP4) antibodies. Methods We prospectively studied adult patients with MOG or AQP4 antibodies who received RTX under an individualized dosing schedule adapted to the biological effect of RTX monitored by memory B‐cell measurement. Memory B cells were counted monthly and when relapse occurred. The biological effect of RTX was considered significant with
ISSN:	0364-5134 1531-8249
DOI:	10.1002/ana.25648