Co-doping of hydroxyapatite with zinc and fluoride improves mechanical and biological properties of hydroxyapatite

Co-doping of hydroxyapatite with zinc and fluoride improves mechanical and biological properties of hydroxyapatite

Hydroxyapatite(HA) co-doped with Zn2+ tand F- ions was synthesized by precipitation method for the first time in this study.FTIR spectroscopy revealed Zn2+ tand F ions incorporation into HA structure.Co-doping of Zn2+ tand F- ions decreased unit cell volume of HA and decreased grain sizes.Zn2+ tor 5...

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Veröffentlicht in:Progress in natural science 2014-08, Vol.24 (4), p.340-349
Hauptverfasser: Uysal, Idil, Severcan, Feride, Tezcaner, Aysen, Evis, Zafer
Format: Artikel
Sprache:eng
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Biocompatibility
Co-doping
Hydroxyapatite
Microhardness
Microstructure
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container_title Progress in natural science
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creator Uysal, Idil
Severcan, Feride
Tezcaner, Aysen
Evis, Zafer
description Hydroxyapatite(HA) co-doped with Zn2+ tand F- ions was synthesized by precipitation method for the first time in this study.FTIR spectroscopy revealed Zn2+ tand F ions incorporation into HA structure.Co-doping of Zn2+ tand F- ions decreased unit cell volume of HA and decreased grain sizes.Zn2+ tor 5 mol% F addition into HA significantly improved its density.Microhardness was increased with Zn2+ taddition and further increase was detected with F co-doping.Zn2+ tand F co-doped samples had higher fracture toughness than pure HA.Zn2+ tincorporation to the structure resulted in an increase in cell proliferation and ALP activity of cells,and further increase was observed with 1 mol%F addition.With superior mechanical properties and biological response 2Zn1 F is a good candidate for biomedical applications.
doi_str_mv 10.1016/j.pnsc.2014.06.004
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subjects Biocompatibility
Co-doping
Hydroxyapatite
Microhardness
Microstructure
title Co-doping of hydroxyapatite with zinc and fluoride improves mechanical and biological properties of hydroxyapatite
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