Enhanced structural stability of adenovirus nanocapsule

Enhanced structural stability of adenovirus nanocapsule

Application of viral vector in gene therapy and vaccination is still limited by their structural stability, which significantly increased avoidable cost in storage and transportation. Herein a non-covalent conjugated low-pH degradable nanocapsule has been adopted to stabilize viral vectors. By utili...

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Veröffentlicht in:Progress in natural science 2014-04, Vol.24 (2), p.171-174
Hauptverfasser: Weng, Ding, Jiang, Ziyue Karen, Jin, Jing, Wu, Lily, Lu, Yunfeng
Format: Artikel
Sprache:eng
Schlagworte:
Adenovirus
nanocapsule
Non-covalent
Non-covalent nanocapsule
stability
Structural
Structural stability
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Zusammenfassung:Application of viral vector in gene therapy and vaccination is still limited by their structural stability, which significantly increased avoidable cost in storage and transportation. Herein a non-covalent conjugated low-pH degradable nanocapsule has been adopted to stabilize viral vectors. By utilizing a luciferase expressing adenovirus, AdCMVLuc, we succeeded in a raise of over 11 folds in AdCMVLuc’s structural stability after 12 days storage at 4 1℃.
ISSN:1002-0071
DOI:10.1016/j.pnsc.2014.03.001