Characterization of terbium-doped nano-hydroxyapatite and surface modification

The control synthesis of nanoparticles was the implementation process of material ideal design. Nano-hydroxyapatite（HAP） was prepared by a hydrothermal method with calcium nitrate and diammonium hydrogen phosphate as raw material, to study its characteristics for morphology modification by arginine-functionalization and doping with rare earth such as Tb~（3＋）. The crystallization, grain size and dispersibility of the sample HAP were analyzed and discussed. The results show that the surface Zeta potential of arginine-functionalized HAP is changed, and the growth rate of HAP is inhibited to a certain extent during the synthesis. The structure of HAP/Arg is not affected during the synthesis by a small amount of rare earth ions doped such as Tb^3＋, and has a single phase of HAP with good dispersibility. The synthesized HAP is also of nano-sized level. Nano-hydroxyapatite argininefunctionalized and doped with rare earth such as Tb^3＋, is suitable for the application of gene delivery as a gene carrier.