Identification of Nedd4 as a novel regulator in Hedgehog signaling

Background Hedgehog （Hh） signaling plays an important role in both embryonic development and postnatal tissue homeostasis. Aberrant Hh activation results in a large variety of cancers. This study was designed to discover novel modulators in Hh signaling pathway.

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Bibliographische Detailangaben
Veröffentlicht in:	Chinese medical journal 2012-11, Vol.125 (21), p.3851-3855
Hauptverfasser:	Luo, Qing-Feng, Chen, Wei, Zhang, Shu-Tian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Endosomal Sorting Complexes Required for Transport - physiology Hedgehog Hedgehog Proteins - physiology HEK293 Cells Humans Mice Nedd4 Ubiquitin Protein Ligases NIH 3T3 Cells Receptors, G-Protein-Coupled - physiology Signal Transduction - physiology Smoothened Receptor Transcription Factors - physiology Ubiquitin-Protein Ligases - physiology Zinc Finger Protein GLI1 信号调节器信号途径刺猬生后胚胎发育调制器鉴定
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Beschreibung
Zusammenfassung:	Background Hedgehog （Hh） signaling plays an important role in both embryonic development and postnatal tissue homeostasis. Aberrant Hh activation results in a large variety of cancers. This study was designed to discover novel modulators in Hh signaling pathway.
ISSN:	0366-6999 2542-5641
DOI:	10.3760/cma.j.issn.0366-6999.2012.21.020