Transfect bone marrow stromal cells with pcDNA3.1-VEGF to construct tissue engineered bone in defect repair

Background We previously showed that nano-hydroxyapatite/carboxymethyl chitosan （n-Ha/CMCS） displayed excellent mechanical properties, good degradation rates and exceptional biocompatibility, with negligible toxicity. The aim of this study was to determine the effect of the same composite with vascu...

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Veröffentlicht in:	Chinese medical journal 2012-03, Vol.125 (5), p.906-911
Hauptverfasser:	Si, Hai-peng, Lu, Zhi-hua, Lin, Yong-liang, Li, Jing-jing, Yin, Qing-feng, Zhao, Dong-mei, Wang, Shao-jin, Li, Jian-min, Wang, Hai-bin, Zhang, Xi-hua
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Diseases - surgery Bone Marrow Cells - cytology Rabbits Stromal Cells - cytology Tissue Engineering - methods Tissue Scaffolds - chemistry Vascular Endothelial Growth Factor A - chemistry 修复生物相容性组织工程血管内皮生长因子质粒转染骨缺损骨髓基质干细胞
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Zusammenfassung:	Background We previously showed that nano-hydroxyapatite/carboxymethyl chitosan （n-Ha/CMCS） displayed excellent mechanical properties, good degradation rates and exceptional biocompatibility, with negligible toxicity. The aim of this study was to determine the effect of the same composite with vascular endothelial growth factor （VEGF）transfected bone marrow stromal cells （BMSCs） in a rabbit radial defect model.
ISSN:	0366-6999 2542-5641
DOI:	10.3760/cma.j.issn.0366-6999.2012.05.031