Three-dimensional cultures of human endometrial cells on Matrigel mimic in vivo morphology

Background The regulation of endometrial physiology and morphogenesis by the paracrine effectors has been well established using in vivo studies. A more complete understanding of the endometrial function has been delayed due, in part, to a lack of appropriate culture models. In this study, we aimed to simulate the in vivo three-dimensional （3-D） growth pattern of endometrial cells using a 3-D in vitro culture system.