Relationship between event-related potential P300 and first episode schizophrenia

Although P300 abnormalities of event-related .potentials （ERPs） are consistently reported among schizophrenic patients as being the most compelling indices of their brain dysfunction, whether they are trait markers or state markers of schizophrenia remains in controversy. To shed a light on this point, we made a longitudinal study of P300 among first episode schizophrenic patients, from no medication until the patients had been medicated for 12 weeks.