Signal transducers and activators of transcription 3 mediates up-regulation of angiotensin Ⅱ-induced tissue inhibitor of metalloproteinase-1 expression in cultured human senescent fibroblasts
Backgroud Angiotensin Ⅱ （Ang Ⅱ）, a principal effector of renin-angiotensin system （RAS） and increased in aging tissues, can stimulate JAK/STAT pathway via the G-protein-coupled Ang Ⅱ receptor type Ⅰ （AT1） and induce nuclear translocation of signal transducers and activators of transcription （STAT）....
Gespeichert in:
| Veröffentlicht in: | Chinese medical journal 2006-07, Vol.119 (13), p.1094-1102 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1102 |
|---|---|
| container_issue | 13 |
| container_start_page | 1094 |
| container_title | Chinese medical journal |
| container_volume | 119 |
| creator | Wang, Xiao-dan Chen, Xiang-mei Wang, Jian-zhong Hong, Quan Feng, Zhe Fu, Bo Zhou, Feng Wang, Feng-yang Fan, Dai-ming |
| description | Backgroud Angiotensin Ⅱ （Ang Ⅱ）, a principal effector of renin-angiotensin system （RAS） and increased in aging tissues, can stimulate JAK/STAT pathway via the G-protein-coupled Ang Ⅱ receptor type Ⅰ （AT1） and induce nuclear translocation of signal transducers and activators of transcription （STAT）. To further explore the role of Ang Ⅱ in aging, we examined the effect of Ang Ⅱ on human replicative senescent diploid fibroblast WI-38 cells. |
| doi_str_mv | 10.1097/00029330-200607010-00006 |
| format | Article |
| fullrecord | <record><control><sourceid>wanfang_jour_proqu</sourceid><recordid>TN_cdi_wanfang_journals_zhcmj200613006</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cqvip_id>22272324</cqvip_id><wanfj_id>zhcmj200613006</wanfj_id><sourcerecordid>zhcmj200613006</sourcerecordid><originalsourceid>FETCH-LOGICAL-c421t-9247f1cfd21612dee12265068638b1d0ec82e4578f71adc0a977159b11f4678d3</originalsourceid><addsrcrecordid>eNpFkcGOFCEQhjtG446rr2CIB28o0N10czQbXU028aCeCU1XzzB2wywFrnrfB_FRfBWfRHpndC8Q4P__quKrKsLZK85U95oxJlRdMyoYk6xjnNFyxeSDaiPaRtBWNvxhtWG1lFQqpc6qJ4j7YmrbTj6uzrjs60aJflP9_uS23swkReNxzBYiEuNHYmxy30wK5Rim46uN7pBc8KQmC4zOJECSDzTCNs_m7qEojd-6kMCj8-TP7S_q_Bo6kuQQMxDnd25wJXbVLpDMPIdDLAbnDQLlBL4fIiCuaSXB5jnlWOy7vBhPEDygBZ_I5IYYhtlgwqfVo8nMCM9O-3n15d3bzxfv6dXHyw8Xb66obQRPVImmm7idRsElFyMAF0K2TPay7gc-MrC9gKbt-qnjZrTMqK7jrRo4nxrZ9WN9Xr085t4YP5Ux9T7kWL4O9c-dXfYrCV6X5V5YBrvOgEkvrnQ9z8ZDyKjXklwpUYT9UWhjQIww6UN0i4k_NGd65az_cdb_Oes7zsX6_FQjDwXGvfEEtghenLJ3wW-vXel3MPbr5GbQQohO1KKp_wKED7R0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68631992</pqid></control><display><type>article</type><title>Signal transducers and activators of transcription 3 mediates up-regulation of angiotensin Ⅱ-induced tissue inhibitor of metalloproteinase-1 expression in cultured human senescent fibroblasts</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Wang, Xiao-dan ; Chen, Xiang-mei ; Wang, Jian-zhong ; Hong, Quan ; Feng, Zhe ; Fu, Bo ; Zhou, Feng ; Wang, Feng-yang ; Fan, Dai-ming</creator><creatorcontrib>Wang, Xiao-dan ; Chen, Xiang-mei ; Wang, Jian-zhong ; Hong, Quan ; Feng, Zhe ; Fu, Bo ; Zhou, Feng ; Wang, Feng-yang ; Fan, Dai-ming</creatorcontrib><description>Backgroud Angiotensin Ⅱ （Ang Ⅱ）, a principal effector of renin-angiotensin system （RAS） and increased in aging tissues, can stimulate JAK/STAT pathway via the G-protein-coupled Ang Ⅱ receptor type Ⅰ （AT1） and induce nuclear translocation of signal transducers and activators of transcription （STAT）. To further explore the role of Ang Ⅱ in aging, we examined the effect of Ang Ⅱ on human replicative senescent diploid fibroblast WI-38 cells.</description><identifier>ISSN: 0366-6999</identifier><identifier>EISSN: 2542-5641</identifier><identifier>DOI: 10.1097/00029330-200607010-00006</identifier><identifier>PMID: 16834928</identifier><language>eng</language><publisher>China: Department of Gastroenterology,Fourth Military Medical University,Xi'an 710032,China%Department of Nephrology, General Hospital of People's Liberation Army, Beijing 100853, China%Institute of Genome Research, Tsinghua University, Beijing 100084,China%Department of Gastroenterology,Fourth Military Medical University,Xi'an 710032,China</publisher><subject>Angiotensin II - pharmacology ; Cells, Cultured ; Cellular Senescence ; DNA - metabolism ; Fibroblasts - metabolism ; Gene Expression Regulation ; Humans ; MAP Kinase Signaling System ; STAT3 Transcription Factor - physiology ; Tissue Inhibitor of Metalloproteinase-1 - genetics ; Up-Regulation ; 信号转导 ; 活化剂 ; 血管紧缩素 ; 金属蛋白酶-1</subject><ispartof>Chinese medical journal, 2006-07, Vol.119 (13), p.1094-1102</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-9247f1cfd21612dee12265068638b1d0ec82e4578f71adc0a977159b11f4678d3</citedby><cites>FETCH-LOGICAL-c421t-9247f1cfd21612dee12265068638b1d0ec82e4578f71adc0a977159b11f4678d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/85656X/85656X.jpg</thumbnail><link.rule.ids>314,780,784,864,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16834928$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Xiao-dan</creatorcontrib><creatorcontrib>Chen, Xiang-mei</creatorcontrib><creatorcontrib>Wang, Jian-zhong</creatorcontrib><creatorcontrib>Hong, Quan</creatorcontrib><creatorcontrib>Feng, Zhe</creatorcontrib><creatorcontrib>Fu, Bo</creatorcontrib><creatorcontrib>Zhou, Feng</creatorcontrib><creatorcontrib>Wang, Feng-yang</creatorcontrib><creatorcontrib>Fan, Dai-ming</creatorcontrib><title>Signal transducers and activators of transcription 3 mediates up-regulation of angiotensin Ⅱ-induced tissue inhibitor of metalloproteinase-1 expression in cultured human senescent fibroblasts</title><title>Chinese medical journal</title><addtitle>Chinese Medical Journal</addtitle><description>Backgroud Angiotensin Ⅱ （Ang Ⅱ）, a principal effector of renin-angiotensin system （RAS） and increased in aging tissues, can stimulate JAK/STAT pathway via the G-protein-coupled Ang Ⅱ receptor type Ⅰ （AT1） and induce nuclear translocation of signal transducers and activators of transcription （STAT）. To further explore the role of Ang Ⅱ in aging, we examined the effect of Ang Ⅱ on human replicative senescent diploid fibroblast WI-38 cells.</description><subject>Angiotensin II - pharmacology</subject><subject>Cells, Cultured</subject><subject>Cellular Senescence</subject><subject>DNA - metabolism</subject><subject>Fibroblasts - metabolism</subject><subject>Gene Expression Regulation</subject><subject>Humans</subject><subject>MAP Kinase Signaling System</subject><subject>STAT3 Transcription Factor - physiology</subject><subject>Tissue Inhibitor of Metalloproteinase-1 - genetics</subject><subject>Up-Regulation</subject><subject>信号转导</subject><subject>活化剂</subject><subject>血管紧缩素</subject><subject>金属蛋白酶-1</subject><issn>0366-6999</issn><issn>2542-5641</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkcGOFCEQhjtG446rr2CIB28o0N10czQbXU028aCeCU1XzzB2wywFrnrfB_FRfBWfRHpndC8Q4P__quKrKsLZK85U95oxJlRdMyoYk6xjnNFyxeSDaiPaRtBWNvxhtWG1lFQqpc6qJ4j7YmrbTj6uzrjs60aJflP9_uS23swkReNxzBYiEuNHYmxy30wK5Rim46uN7pBc8KQmC4zOJECSDzTCNs_m7qEojd-6kMCj8-TP7S_q_Bo6kuQQMxDnd25wJXbVLpDMPIdDLAbnDQLlBL4fIiCuaSXB5jnlWOy7vBhPEDygBZ_I5IYYhtlgwqfVo8nMCM9O-3n15d3bzxfv6dXHyw8Xb66obQRPVImmm7idRsElFyMAF0K2TPay7gc-MrC9gKbt-qnjZrTMqK7jrRo4nxrZ9WN9Xr085t4YP5Ux9T7kWL4O9c-dXfYrCV6X5V5YBrvOgEkvrnQ9z8ZDyKjXklwpUYT9UWhjQIww6UN0i4k_NGd65az_cdb_Oes7zsX6_FQjDwXGvfEEtghenLJ3wW-vXel3MPbr5GbQQohO1KKp_wKED7R0</recordid><startdate>20060705</startdate><enddate>20060705</enddate><creator>Wang, Xiao-dan</creator><creator>Chen, Xiang-mei</creator><creator>Wang, Jian-zhong</creator><creator>Hong, Quan</creator><creator>Feng, Zhe</creator><creator>Fu, Bo</creator><creator>Zhou, Feng</creator><creator>Wang, Feng-yang</creator><creator>Fan, Dai-ming</creator><general>Department of Gastroenterology,Fourth Military Medical University,Xi'an 710032,China%Department of Nephrology, General Hospital of People's Liberation Army, Beijing 100853, China%Institute of Genome Research, Tsinghua University, Beijing 100084,China%Department of Gastroenterology,Fourth Military Medical University,Xi'an 710032,China</general><general>Department of Nephrology, General Hospital of People's Liberation Army, Beijing 100853, China</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W94</scope><scope>WU4</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>20060705</creationdate><title>Signal transducers and activators of transcription 3 mediates up-regulation of angiotensin Ⅱ-induced tissue inhibitor of metalloproteinase-1 expression in cultured human senescent fibroblasts</title><author>Wang, Xiao-dan ; Chen, Xiang-mei ; Wang, Jian-zhong ; Hong, Quan ; Feng, Zhe ; Fu, Bo ; Zhou, Feng ; Wang, Feng-yang ; Fan, Dai-ming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-9247f1cfd21612dee12265068638b1d0ec82e4578f71adc0a977159b11f4678d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Angiotensin II - pharmacology</topic><topic>Cells, Cultured</topic><topic>Cellular Senescence</topic><topic>DNA - metabolism</topic><topic>Fibroblasts - metabolism</topic><topic>Gene Expression Regulation</topic><topic>Humans</topic><topic>MAP Kinase Signaling System</topic><topic>STAT3 Transcription Factor - physiology</topic><topic>Tissue Inhibitor of Metalloproteinase-1 - genetics</topic><topic>Up-Regulation</topic><topic>信号转导</topic><topic>活化剂</topic><topic>血管紧缩素</topic><topic>金属蛋白酶-1</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Xiao-dan</creatorcontrib><creatorcontrib>Chen, Xiang-mei</creatorcontrib><creatorcontrib>Wang, Jian-zhong</creatorcontrib><creatorcontrib>Hong, Quan</creatorcontrib><creatorcontrib>Feng, Zhe</creatorcontrib><creatorcontrib>Fu, Bo</creatorcontrib><creatorcontrib>Zhou, Feng</creatorcontrib><creatorcontrib>Wang, Feng-yang</creatorcontrib><creatorcontrib>Fan, Dai-ming</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-自然科学</collection><collection>中文科技期刊数据库-自然科学-生物科学</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><jtitle>Chinese medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Xiao-dan</au><au>Chen, Xiang-mei</au><au>Wang, Jian-zhong</au><au>Hong, Quan</au><au>Feng, Zhe</au><au>Fu, Bo</au><au>Zhou, Feng</au><au>Wang, Feng-yang</au><au>Fan, Dai-ming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Signal transducers and activators of transcription 3 mediates up-regulation of angiotensin Ⅱ-induced tissue inhibitor of metalloproteinase-1 expression in cultured human senescent fibroblasts</atitle><jtitle>Chinese medical journal</jtitle><addtitle>Chinese Medical Journal</addtitle><date>2006-07-05</date><risdate>2006</risdate><volume>119</volume><issue>13</issue><spage>1094</spage><epage>1102</epage><pages>1094-1102</pages><issn>0366-6999</issn><eissn>2542-5641</eissn><abstract>Backgroud Angiotensin Ⅱ （Ang Ⅱ）, a principal effector of renin-angiotensin system （RAS） and increased in aging tissues, can stimulate JAK/STAT pathway via the G-protein-coupled Ang Ⅱ receptor type Ⅰ （AT1） and induce nuclear translocation of signal transducers and activators of transcription （STAT）. To further explore the role of Ang Ⅱ in aging, we examined the effect of Ang Ⅱ on human replicative senescent diploid fibroblast WI-38 cells.</abstract><cop>China</cop><pub>Department of Gastroenterology,Fourth Military Medical University,Xi'an 710032,China%Department of Nephrology, General Hospital of People's Liberation Army, Beijing 100853, China%Institute of Genome Research, Tsinghua University, Beijing 100084,China%Department of Gastroenterology,Fourth Military Medical University,Xi'an 710032,China</pub><pmid>16834928</pmid><doi>10.1097/00029330-200607010-00006</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0366-6999 |
| ispartof | Chinese medical journal, 2006-07, Vol.119 (13), p.1094-1102 |
| issn | 0366-6999 2542-5641 |
| language | eng |
| recordid | cdi_wanfang_journals_zhcmj200613006 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Angiotensin II - pharmacology Cells, Cultured Cellular Senescence DNA - metabolism Fibroblasts - metabolism Gene Expression Regulation Humans MAP Kinase Signaling System STAT3 Transcription Factor - physiology Tissue Inhibitor of Metalloproteinase-1 - genetics Up-Regulation 信号转导 活化剂 血管紧缩素 金属蛋白酶-1 |
| title | Signal transducers and activators of transcription 3 mediates up-regulation of angiotensin Ⅱ-induced tissue inhibitor of metalloproteinase-1 expression in cultured human senescent fibroblasts |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T04%3A05%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-wanfang_jour_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Signal%20transducers%20and%20activators%20of%20transcription%203%20mediates%20up-regulation%20of%20angiotensin%20%E2%85%A1-induced%20tissue%20inhibitor%20of%20metalloproteinase-1%20expression%20in%20cultured%20human%20senescent%20fibroblasts&rft.jtitle=Chinese%20medical%20journal&rft.au=Wang,%20Xiao-dan&rft.date=2006-07-05&rft.volume=119&rft.issue=13&rft.spage=1094&rft.epage=1102&rft.pages=1094-1102&rft.issn=0366-6999&rft.eissn=2542-5641&rft_id=info:doi/10.1097/00029330-200607010-00006&rft_dat=%3Cwanfang_jour_proqu%3Ezhcmj200613006%3C/wanfang_jour_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=68631992&rft_id=info:pmid/16834928&rft_cqvip_id=22272324&rft_wanfj_id=zhcmj200613006&rfr_iscdi=true |