Signal transducers and activators of transcription 3 mediates up-regulation of angiotensin Ⅱ-induced tissue inhibitor of metalloproteinase-1 expression in cultured human senescent fibroblasts

Backgroud Angiotensin Ⅱ （Ang Ⅱ）, a principal effector of renin-angiotensin system （RAS） and increased in aging tissues, can stimulate JAK/STAT pathway via the G-protein-coupled Ang Ⅱ receptor type Ⅰ （AT1） and induce nuclear translocation of signal transducers and activators of transcription （STAT）....

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Veröffentlicht in:	Chinese medical journal 2006-07, Vol.119 (13), p.1094-1102
Hauptverfasser:	Wang, Xiao-dan, Chen, Xiang-mei, Wang, Jian-zhong, Hong, Quan, Feng, Zhe, Fu, Bo, Zhou, Feng, Wang, Feng-yang, Fan, Dai-ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II - pharmacology Cells, Cultured Cellular Senescence DNA - metabolism Fibroblasts - metabolism Gene Expression Regulation Humans MAP Kinase Signaling System STAT3 Transcription Factor - physiology Tissue Inhibitor of Metalloproteinase-1 - genetics Up-Regulation 信号转导活化剂血管紧缩素金属蛋白酶-1
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Zusammenfassung:	Backgroud Angiotensin Ⅱ （Ang Ⅱ）, a principal effector of renin-angiotensin system （RAS） and increased in aging tissues, can stimulate JAK/STAT pathway via the G-protein-coupled Ang Ⅱ receptor type Ⅰ （AT1） and induce nuclear translocation of signal transducers and activators of transcription （STAT）. To further explore the role of Ang Ⅱ in aging, we examined the effect of Ang Ⅱ on human replicative senescent diploid fibroblast WI-38 cells.
ISSN:	0366-6999 2542-5641
DOI:	10.1097/00029330-200607010-00006