Imiquimod attenuates airway inflammation and decreases the expression of thymus and activation regulated chemokine in allergic asthmatic mice

Imiquimod is an imidazoquinoline derivative. Some studies have shown that imiquimod modulates the Th1/Th2 response by inducing the production of Th1 cytokines IFN-γ and interleukin （IL）-12. and by inhibiting Th2 cytokines IL-4 and IL-5. These data suggest that imiquimod has therapeutic appli . catio...

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Veröffentlicht in:	Chinese medical journal 2006-03, Vol.119 (5), p.412-416
Hauptverfasser:	Jin, Shu-xian, Yin, Kai-sheng, Bian, Tao, Sun, Pei-li
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoquinolines - pharmacology Aminoquinolines - therapeutic use Animals Asthma - drug therapy Asthma - immunology Asthma - pathology Bronchoalveolar Lavage Fluid - cytology Cell Count Chemokine CCL17 Chemokine CCL22 Chemokines, CC - analysis Chemokines, CC - genetics Cytokines - biosynthesis Flow Cytometry Interleukin-4 - antagonists & inhibitors Male Mice Mice, Inbred BALB C RNA, Messenger - analysis Signal Transduction - drug effects STAT6 Transcription Factor - analysis STAT6 Transcription Factor - antagonists & inhibitors STAT6 Transcription Factor - genetics 变态反应哮喘基因表达炎症胸腺
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Zusammenfassung:	Imiquimod is an imidazoquinoline derivative. Some studies have shown that imiquimod modulates the Th1/Th2 response by inducing the production of Th1 cytokines IFN-γ and interleukin （IL）-12. and by inhibiting Th2 cytokines IL-4 and IL-5. These data suggest that imiquimod has therapeutic appli . cations in atopic diseases such as allergic asthma that are associated with overexpression of Th2 cytokines.
ISSN:	0366-6999
DOI:	10.1097/00029330-200603010-00011