An enriched environment improves cognitive performance in mice from the senescence-accelerated prone mouse 8 strain Role of upregulated neurotrophic factor expression in the hippocampus
In this study,we examined 3-month-old female mice from the senescence-accelerated prone mouse 8 strain and age-matched homologous normal aging female mice from the senescence accelerated-resistant mouse 1 strain.Mice from each strain were housed in an enriched environment(including a platform,runnin...
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Veröffentlicht in: | Neural regeneration research 2012-08, Vol.7 (23), p.1797-1804 |
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Sprache: | eng |
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Zusammenfassung: | In this study,we examined 3-month-old female mice from the senescence-accelerated prone mouse 8 strain and age-matched homologous normal aging female mice from the senescence accelerated-resistant mouse 1 strain.Mice from each strain were housed in an enriched environment(including a platform,running wheels,tunnel,and some toys)or a standard environment for 3 months.The mice housed in the enriched environment exhibited shorter escape latencies and a greater percentage of time in the target quadrant in the Morris water maze test,and they exhibited reduced errors and longer latencies in step-down avoidance experiments compared with mice housed in the standard environment.Correspondently,brain-derived neurotrophic factor mRNA and protein ex- pression in the hippocampus was significantly higher in mice housed in the enriched environment compared with those housed in the standard environment,and the level of hippocampal brain-derived neurotrophic factor protein was positively correlated with the learning and memory abilities of mice from the senescence-accelerated prone mouse 8 strain.These results suggest that an enriched environment improved cognitive performance in mice form the senescence-accelerated prone mouse 8 strain by increasing brain-derived neurotrophic factor expression in the hippocampus. |
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ISSN: | 1673-5374 1876-7958 |
DOI: | 10.3969/j.issn.1673-5374.2012.23.006 |