Provincial distribution of three HIV-1 resistant polymorphisms (CCR5-Delta32, CCR2-64I, and SDF1-3' A) in China

CCR5-Delta32, CCR2-64I, mutants in two chemokine receptors and SDF1-3'A, mutant in a ligand gene, can delay AIDS pathogenesis. The distribution of the three polymorphic loci was studied in 1 046 DNA samples from 26 provinces (cities) in China. No CCR5-Delta 32 was observed. CCR2-64I and SDF1-3&...

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Veröffentlicht in:	Science China. Life sciences 2000-02, Vol.43 (1), p.16-20
Hauptverfasser:	Xiao, J, Hu, F, Xu, H, Su, B, Jiang, Y, Luo, J, Zhang, W, Tan, J, Jin, L, Lu, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome AIDS CC chemokine receptors CCR2 protein CCR5 protein Chemokine receptors China Epidemiology HIV Human immunodeficiency virus Human immunodeficiency virus 1 Monocyte chemoattractant protein 1 Mutants SDF-1 protein
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Zusammenfassung:	CCR5-Delta32, CCR2-64I, mutants in two chemokine receptors and SDF1-3'A, mutant in a ligand gene, can delay AIDS pathogenesis. The distribution of the three polymorphic loci was studied in 1 046 DNA samples from 26 provinces (cities) in China. No CCR5-Delta 32 was observed. CCR2-64I and SDF1-3' A had reverse distribution cline from south to north in China, with average frequency of 20.8% and 24.8% respectively. Relative hazard was evaluated. Important information to the epidemiology of AIDS and the origin and spread of these polymorphic loci in Chinese was provided.
ISSN:	1006-9305 1674-7305 1862-2798 1869-1889
DOI:	10.1007/BF02881713