Discovery of prenylated indole alkaloid and natural xanthone from cold-seep sediment derived fungus Talaromyces funiculosus SD-523

A new prenylated indole alkaloid 11, 17- epi -mangrovamide A ( 1 ), a new natural occurring product, 1,7-dihydroxy-6-methyl-8-hydroxymethyl-xanthone ( 2 ), two known alkaloids, mangrovamide A ( 3 ) and mangrovamide G ( 4 ), and four known polyketide derivatives ( 5–8 ) were isolated and identified f...

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Veröffentlicht in:	Journal of oceanology and limnology 2023-05, Vol.41 (3), p.1152-1158
Hauptverfasser:	Wang, Yanan, Li, Xiaoming, Lü, Fengyi, Yang, Suiqun, Meng, Linghong, Wang, Bingui
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids Analytical methods Antibacterial activity Antibiotics Biology Chromatography Circular dichroism Dichroism Earth and Environmental Science Earth Sciences Fungi Ionization Laboratories Limnology Marine biology Mass spectroscopy Metabolites NMR Nuclear magnetic resonance Oceanography Probability theory Quantum chemistry Science Sediment Sediments Talaromyces funiculosus
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Zusammenfassung:	A new prenylated indole alkaloid 11, 17- epi -mangrovamide A ( 1 ), a new natural occurring product, 1,7-dihydroxy-6-methyl-8-hydroxymethyl-xanthone ( 2 ), two known alkaloids, mangrovamide A ( 3 ) and mangrovamide G ( 4 ), and four known polyketide derivatives ( 5–8 ) were isolated and identified from the cold-seep sediment derived fungal strain Talaromyces funiculosus SD-523. Their structures were elucidated by combination of nuclear magnetic resonance (NMR), high resolution electrospray ionization mass spectroscopy (HRESIMS), quantum chemical electronic circular dichroism (ECD), and DP4+ probability analysis as well as by comparison of the data with literature reports. All isolated compounds were tested for antibacterial activities.
ISSN:	2096-5508 2523-3521
DOI:	10.1007/s00343-022-2061-x