Eco-friendly iron-catalyzed oxidation of unstrained tertiary aromatic alcohols to ketones

Eco-friendly iron-catalyzed oxidation of unstrained tertiary aromatic alcohols to ketones

A general, facile and eco-friendly iron catalysis enables oxidation of unstrained tertiary aromatic alcohols to ketones through C−C bond cleavage even with H2O2 as the oxidant. Notably, this transformation can tolerate oxidation-labile functional groups. The robustness of this method is further demo...

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Veröffentlicht in:Chinese chemical letters 2024-01, Vol.35 (1), p.108835-253, Article 108835
Hauptverfasser: Zhu, Shanmei, Hu, Penghui, Guo, Mengying, Zhao, Linlin, Yang, Linlin, Gu, Wei-Jin, Han, Wei
Format: Artikel
Sprache:eng
Schlagworte:
C−C bond cleavage
H2O2
Iron catalysis
Late-stage functionalization
Oxidation
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Zusammenfassung:A general, facile and eco-friendly iron catalysis enables oxidation of unstrained tertiary aromatic alcohols to ketones through C−C bond cleavage even with H2O2 as the oxidant. Notably, this transformation can tolerate oxidation-labile functional groups. The robustness of this method is further demonstrated on the late-stage oxidation of complex bioactive molecules. Eco-friendly iron-catalyzed selective oxidation unstrained C(sp3)-C(sp3) bond cleavage of tertiary aromatic alcohols to ketones even with H2O2 as the oxidant is suitable for late-stage oxidation of complex small molecules. [Display omitted]
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2023.108835