ICG/Lecithin: A promising theranostic agent for simultaneous therapy and diagnosis of MRI and PAI

A chronic liver disease usually results in iron accumulation, and an excess of iron will further aggravate liver injury, forming a vicious circle. Likewise, it also plays a significant role in other organs when it comes to iron metabolism. A long time passes between the time it takes to break through to MRI-based iron diagnosis and its ability to distinguish the types of iron accumulation accurately and quickly. This work highlighted a new type of iron accumulation treatment solution integrated with diagnosis and treatment. A chelating method for ICG and Leci that can assist PAI and MRI to achieve better diagnostic and therapeutic effects. This work revealed biomaterial engineering techniques are being adapted to address clinical medical problems through cutting-edge research. [Display omitted] ICG can be a contrast agent for MRI to provide a greater degree of accuracy in the identification of iron. Using supramolecular assembly to chelate ICG with Lecithin to improve PAI detection efficiency can be a complement for MRI iron overload diagnosis. The ICG/Lecithin system is a comprehensive treatment with a diagnosis program for iron overloaded livers.