Hydrogen-bond locked purine chromophores with high photostability for lipid droplets imaging in cells and tissues

Recently,hydrogen-bonding has attracted extensive attention in the design of chromophores.Here,a new class of hydrogen-bond locked purine chromophores(HOPs)were reported by introducing a hy-droxyphenyl group into the C(6)position of purine.The intramolecular hydrogen bond plays a dominant role to light up these probes.As a bonus,HOPs show high photostability.Moreover,HOPs exhibit remark-able capability for the specific lipid droplets imaging in living cells with excellent biocompatibility and are also potential for diagnosing fatty liver diseases.These results bring important new insights into the photophysics of the purine-based chromophores and provide a new scaffold with high photostability for bioimaging.