MUC1 vaccines using β-cyclodextrin grafted chitosan (CS-g-CD) as carrier via host-guest interaction elicit robust immune responses

We construct MUC1 vaccines using β-cyclodextrin grafted chitosan (CS-g-CD) as carrier via host-guest interaction. These vaccines based on non-covalent assembling can provoke robust immune responses, including high level of specific antibodies and cytokines. The induced antibodies can specifically recognize tumor cells and mediate cytotoxicity against tumor cells. These results indicate that CS-g-CD with strong immunostimulatory activities can be a straightforward platform for peptide-based vaccine construction. β-Cyclodextrin grafted chitosan (CS-g-CD) was used for constructing MUC1 vaccines via host-guest interaction which elicit robust immune responses. The induced antibodies can specifically recognize tumor cells and mediate cytotoxicity against tumor cells. [Display omitted]