A GSH-responsive PET-based fluorescent probe for cancer cells imaging

A GSH-responsive PET-based fluorescent probe for cancer cells imaging

An efficient PET-based probe, in which the ferrocene quencher and the naphthalimide fluorophore are linked by a disulfide bond, has been developed. This probe can be activated by GSH with fluorescence a turn-on response for blocking the PET process. In addition, it was successfully applied for disti...

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Veröffentlicht in:Chinese chemical letters 2021-04, Vol.32 (4), p.1541-1544
Hauptverfasser: Li, Xue, Wang, Huaying, Zhang, Youhui, Cao, Qianyong, Chen, Yong
Format: Artikel
Sprache:eng
Schlagworte:
Cancer cells imaging
Chemistry
Chemistry, Multidisciplinary
Fluorescent sensor
GSH sensing
Photoinduced electron transfer
Physical Sciences
Science & Technology
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Zusammenfassung:An efficient PET-based probe, in which the ferrocene quencher and the naphthalimide fluorophore are linked by a disulfide bond, has been developed. This probe can be activated by GSH with fluorescence a turn-on response for blocking the PET process. In addition, it was successfully applied for distinguishing cancer cells from normal cells. [Display omitted] An efficient PET-based probe, in which the ferrocene quencher and the naphthalimide fluorophore are linked by a disulfide bond, has been developed. This probe can be activated by GSH with fluorescence a turn-on response for blocking the PET process. In addition, it was successfully applied for distinguishing cancer cells from normal cells
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2020.10.047