Design of high stability thin-film transistor biosensor for the diagnosis of bladder cancer

The high stability indium gallium zinc oxide field effect transistor (IGZO-FET) biosensorwas designed for efficient identification of bladder cancer biomarkers from human urine samples. This noninvasive detection approach holds great potential in the application of portable digital bladder cancer diagnosis devices. [Display omitted] Bladder cancer is the most common malignant tumor in the urinary system, with high morbidity, mortality and recurrence after surgery. However, current bladder cancer urine diagnosis methods are limited by the low accuracy and specificity due to the low abundance of bladder cancer biomarkers in the urine with complex biological environments. Herein, we present a high stability indium gallium zinc oxide field effect transistor (IGZO-FET) biosensor for efficient identification of bladder cancer biomarkers from human urine samples. The recognition molecular functionalized IGZO-FET biosensor exhibits stable electronic and sensing performance due to the large-area fabrication of IGZO thin-film FET. Owing to the excellent electrical performance of IGZO-FET, the IGZO-FET biosensor exhibits high sensitivity and extremely low detection limit (2.7 amol/L) towards bladder cancer biomarkers. The IGZO-FET biosensor is also able to directly detect bladder tumor biomarker in human urine with high sensitivity and specificity, and could differentiate bladder cancer patients’ urine samples from healthy donors effectively. These results indicate that our designed high-performance biosensor shows great potential in the application of portable digital bladder cancer diagnosis devices.