Diastereo- and enantioselective palladium-catalyzed dearomative [4 + 2] cycloaddition of 3-nitroindoles

Diastereo- and enantioselective palladium-catalyzed dearomative [4 + 2] cycloaddition of 3-nitroindoles

[Display omitted] A Pd-catalyzed asymmetric decarboxylative [4 + 2] cycloaddition of 3-nitroindoles and vinyl benzoxazinanones is developed through a dearomatization approach. The reaction provides an efficient protocol for constructing a series of chiral tetrahydro-5H-indolo[2,3-b]quinolines in hig...

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Veröffentlicht in:Chinese chemical letters 2019-08, Vol.30 (8), p.1512-1514
Hauptverfasser: Suo, Jia-Jia, Du, Juan, Jiang, Yang-Jie, Chen, Di, Ding, Chang-Hua, Hou, Xue-Long
Format: Artikel
Sprache:eng
Schlagworte:
3-Nitroindole
[4 + 2] cycloaddition
Asymmetric catalysis
Palladium
Vinyl benzoxazinanone
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Zusammenfassung:[Display omitted] A Pd-catalyzed asymmetric decarboxylative [4 + 2] cycloaddition of 3-nitroindoles and vinyl benzoxazinanones is developed through a dearomatization approach. The reaction provides an efficient protocol for constructing a series of chiral tetrahydro-5H-indolo[2,3-b]quinolines in high yields and with excellent diastereo- and enantioselectivities.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2019.04.028