Synthesis of polysubstituted pyrroles via a gold(I)-catalyzed tandem three-component reaction at room temperature

A gold(I)-catalyzed three-component reaction of β-nitrostyrenes with 1,3-dicarbonyl compounds and primary amines to form polysubstituted pyrroles has been developed at room temperature in ethanol. The key advantages of the three-component reaction are the mild reaction conditions and environmentally...

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Veröffentlicht in:Chinese chemical letters 2018-12, Vol.29 (12), p.1893-1896
Hauptverfasser: Li, Li, Chen, Qi, Xiong, Xiaonan, Zhang, Chuang, Qian, Jingjing, Shi, Jie, An, Qiong, Zhang, Ming
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Sprache:eng
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Zusammenfassung:A gold(I)-catalyzed three-component reaction of β-nitrostyrenes with 1,3-dicarbonyl compounds and primary amines to form polysubstituted pyrroles has been developed at room temperature in ethanol. The key advantages of the three-component reaction are the mild reaction conditions and environmentally safer solvent [Display omitted] A gold(I)-catalyzed three-component reaction of β-nitrostyrenes with 1,3-dicarbonyl compounds and primary amines to form polysubstituted pyrroles has been developed at room temperature in ethanol. The key advantages of the three-component reaction are the mild reaction conditions and environmentally safer solvent.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2018.09.004