First total synthesis of isoquinolinone alkaloid marinamide and its methyl ester

The first total synthesis of isoquinolinone alkaloid marinamide 1 and its methyl ester 2 was described. The key steps involved a regioselective Frieclel-Crafts reaction of 1-benzyl-1H-pyrrole to form the intermediate 8.

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Bibliographische Detailangaben
Veröffentlicht in:	Chinese chemical letters 2013-08, Vol.24 (8), p.767-769
Hauptverfasser:	Feng, Cheng-Liang, Zhang, Shu-Guang, Chen, Jun-Qing, Cai, Jin, Ji, Min
Format:	Artikel
Sprache:	eng
Schlagworte:	Isoquinolinone alkaloid Marinamide Methyl ester of marinamide Total synthesis 全合成区域选择性反应异喹啉生物碱甲酯苄基
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Beschreibung
Zusammenfassung:	The first total synthesis of isoquinolinone alkaloid marinamide 1 and its methyl ester 2 was described. The key steps involved a regioselective Frieclel-Crafts reaction of 1-benzyl-1H-pyrrole to form the intermediate 8.
ISSN:	1001-8417 1878-5964
DOI:	10.1016/j.cclet.2013.04.039