Synthesis and biological evaluation of new pyrrolopyrazinone compounds as potential antitumor agents

A series of pyrrolo[1,2-a]pyrazinone compounds （Sa-gf） were synthesized, and their cytotoxic activity against SKOV-3, A549, HeLa cells in vitro were evaluated by the MTF method. Some of the compounds showed potential antitumor activity against three tumor cell lines. Among them, compounds 9c and 9d...

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Veröffentlicht in:	Chinese chemical letters 2013-07, Vol.24 (7), p.619-621
Hauptverfasser:	Meng, Ying, Wang, Guan, Li, Yue, Hou, Kuan, Yuan, Yue, Zhang, Li-Juan, Song, Hong-Rui, Shi, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Antitumor HeLa细胞 Pyrrolopyrazinone Synthesis 化合物合成吡嗪酮抗肿瘤剂抗肿瘤活性生物评价细胞毒活性
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Beschreibung
Zusammenfassung:	A series of pyrrolo[1,2-a]pyrazinone compounds （Sa-gf） were synthesized, and their cytotoxic activity against SKOV-3, A549, HeLa cells in vitro were evaluated by the MTF method. Some of the compounds showed potential antitumor activity against three tumor cell lines. Among them, compounds 9c and 9d showed the most potent cytotoxic activity. The preliminary mechanism of action was discussed.
ISSN:	1001-8417 1878-5964
DOI:	10.1016/j.cclet.2013.04.020