A new ginsengenin containing an oxacyclopentane-ring isolated from the acid hydrolysate of total ginsenosides

Bioassay-guided fractionation of the acid hydrolysate of total ginsenosides of Panax ginseng C.A.Meyer （Araliaceae） led to the isolation of a novel ginsengenin（1）.The structure of 1 was determined as （20S,22S）-dammar-22,25-epoxy-3β,12β,20-triol by extensive spectroscopy and single-crystal X-ray diff...

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Veröffentlicht in:	Chinese chemical letters 2013-06, Vol.24 (6), p.524-526
Hauptverfasser:	Guan, Qing-Xiang, Sun, De-Ya, Liu, Ji-Hua, Li, Wei, Meng, Qin, Geng, Cong, Yin, Jian-Yuan
Format:	Artikel
Sprache:	eng
Schlagworte:	A549细胞 Cytotoxicity Ginsengenin MTT法 Oxacyclopentane X-射线衍射分析人参总皂苷水解产物生物活性细胞毒作用隔绝
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Beschreibung
Zusammenfassung:	Bioassay-guided fractionation of the acid hydrolysate of total ginsenosides of Panax ginseng C.A.Meyer （Araliaceae） led to the isolation of a novel ginsengenin（1）.The structure of 1 was determined as （20S,22S）-dammar-22,25-epoxy-3β,12β,20-triol by extensive spectroscopy and single-crystal X-ray diffraction analyses.The cytotoxicity of 1 was further tested against SWl 116,HCTl 16,and A549 cells by the MTT method,with IC50 values in the range of 2.96-30.9μmol/L.
ISSN:	1001-8417 1878-5964
DOI:	10.1016/j.cclet.2013.03.044