A convenient one-pot three component synthesis of 3-aminoalkylated indoles catalyzed by 3-chlorophenylboronic acid

An efficient protocol was developed for the synthesis of 3-aminoalkylated indoles using 3- chlorophenylboronic acid as a catalyst under ambient temperature conditions.The three-component reaction of indoles,aromatic aldehydes and N-methyl aniline offered corresponding 3-aminoalkylated indoles in exc...

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Veröffentlicht in:	Chinese chemical letters 2013-05, Vol.24 (5), p.422-424
Hauptverfasser:	Goswami, Santosh V., Thorat, Prashant. B., Kadam, Vijay N., Khiste, Sachin A., Bhusare, Sudhakar R.
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Aminoalkylaed indoles 3-Chlorophenylboronic acid Aromatic aldehyde Indoles N-Methylaniline N-甲基苯胺三组分合成吲哚氨基氨烷基氯苯酸催化
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Beschreibung
Zusammenfassung:	An efficient protocol was developed for the synthesis of 3-aminoalkylated indoles using 3- chlorophenylboronic acid as a catalyst under ambient temperature conditions.The three-component reaction of indoles,aromatic aldehydes and N-methyl aniline offered corresponding 3-aminoalkylated indoles in excellent yields.This protocol presents some remarkable features such as mild reaction conditions,simple workup procedure and excellent yields.
ISSN:	1001-8417 1878-5964
DOI:	10.1016/j.cclet.2013.03.024