Synthesis and cytotoxic activity of 3-phenyl-4- substituted-β-carbolines

A new class of 3-phenyl-4-substituted-β-carbolines via iodine-mediated electrophilic cyclization as key step were synthesized and their inhibitory activity against three tumor cell lines was evaluated in vitro. It was found that some of the tested compounds showed better cytotoxicity against HeLa an...

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Veröffentlicht in:	Chinese chemical letters 2012-11, Vol.23 (11), p.1230-1232
Hauptverfasser:	Liu, Liu, Xu, Ying Ying, Yang, Ze Qi, Xiang, Jian Nan, Xu, Guang Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	Cytotoxicity Harmine HeLa细胞 Iodine-mediated cyclization MCF-7细胞 Synthesis β-Carboline 合成咔啉抑制活性细胞毒活性肿瘤细胞株苯基
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Zusammenfassung:	A new class of 3-phenyl-4-substituted-β-carbolines via iodine-mediated electrophilic cyclization as key step were synthesized and their inhibitory activity against three tumor cell lines was evaluated in vitro. It was found that some of the tested compounds showed better cytotoxicity against HeLa and MCF-7 cells than harmine.
ISSN:	1001-8417 1878-5964
DOI:	10.1016/j.cclet.2012.09.010