Separation and identification of moxifloxacin impurities in drug substance by high-performance liquid chromatography coupled with ultraviolet detection and Fourier transform ion cyclotron resonance mass spectrometry
In this paper, a high-performance liquid chromatography coupled with ultraviolet detection and Fourier transform-ion cyclotron resonance mass spectrometry （HPLC-UV/FrICRMS） method was described for the investigation of impurity profile in moxifloxacin （MOX） drug substance and chemical reference subs...
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| Veröffentlicht in: | Chinese chemical letters 2012-10, Vol.23 (10), p.1185-1188 |
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| creator | Wu, Cai Sheng Jia, Zhi Xin Ning, Bao Ming Zhang, Jin Lan Wu, Song |
| description | In this paper, a high-performance liquid chromatography coupled with ultraviolet detection and Fourier transform-ion cyclotron resonance mass spectrometry （HPLC-UV/FrICRMS） method was described for the investigation of impurity profile in moxifloxacin （MOX） drug substance and chemical reference substance. Ten impurities were detected by HPLC-UV, while eight impurities were identified by using the high accurate molecular mass combined with multiple-stage mass spectrometric data and fragmentation rules. In addition, to our knowledge, five impurities were founded for the first time in MOX drug substance. |
| doi_str_mv | 10.1016/j.cclet.2012.09.001 |
| format | Article |
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Ten impurities were detected by HPLC-UV, while eight impurities were identified by using the high accurate molecular mass combined with multiple-stage mass spectrometric data and fragmentation rules. In addition, to our knowledge, five impurities were founded for the first time in MOX drug substance.</description><subject>High-performance liquid chromatography coupled with ultraviolet detection and Fourier transform-ion cyclotron resonance mass spectrometry (HPLC–UV/FTICRMS)</subject><subject>Impurity profile</subject><subject>Moxifloxacin (MOX)</subject><subject>傅里叶变换离子回旋共振质谱</subject><subject>分离</subject><subject>性能</subject><subject>杂质分布</subject><subject>液相色谱</subject><subject>紫外检测器</subject><subject>莫西沙星</subject><subject>鉴定</subject><issn>1001-8417</issn><issn>1878-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNqFUcFu1DAQjRBIlMIXcDEnTkntOJt1DhxQRQGpEgfgbDn2JPGS2KnttBt-lN9hstty5eTxzLx58-Zl2VtGC0ZZfXUotB4hFSVlZUGbglL2LLtgYi_yXVNXzzHGVC4qtn-ZvYrxQGkpBK8vsj_fYVZBJesdUc4Qa8Al21l9TvmOTP5ou9EflbaO2Glegk0WIsGfCUtP4tLGpJwG0q5ksP2QzxA6H6ZTbrR3izVED8FPKvk-qHlYifbLPIIhDzYNZBlTUPfWowBiIIH-t8yNRzIIBOsubiPJVtGrHn0KGAWI3p1oJhUjiTNikQdSWF9nLzo1Rnjz-F5mP28-_bj-kt9--_z1-uNtrnnNUi4aRdtKi4ZXlHaigZrX7a4D0yqhYMfB7LmuGFVlSbVpVMM6AZyxWqhqhxG_zN6f5z4o1ynXywPu7JBR_u6H4692cwRvX5bYyc-dOvgYA3RyDnZSYZWMys1FeZAnF-WGkbSRaBmiPpxRgCLu8Rgyagso2diAaqXx9j_4d4-sg3f9ncUNn2grvuei5hX_C_N1uqI</recordid><startdate>20121001</startdate><enddate>20121001</enddate><creator>Wu, Cai Sheng</creator><creator>Jia, Zhi Xin</creator><creator>Ning, Bao Ming</creator><creator>Zhang, Jin Lan</creator><creator>Wu, Song</creator><general>Elsevier B.V</general><general>State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China%National Institutes for Food and Drug Control Beijing 100050, China%Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>~WA</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>20121001</creationdate><title>Separation and identification of moxifloxacin impurities in drug substance by high-performance liquid chromatography coupled with ultraviolet detection and Fourier transform ion cyclotron resonance mass spectrometry</title><author>Wu, Cai Sheng ; Jia, Zhi Xin ; Ning, Bao Ming ; Zhang, Jin Lan ; Wu, Song</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c361t-89a0b4c893400f89e636b5fedba8ae53ed73c410a220cd9a91f8e31168a458e33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>High-performance liquid chromatography coupled with ultraviolet detection and Fourier transform-ion cyclotron resonance mass spectrometry (HPLC–UV/FTICRMS)</topic><topic>Impurity profile</topic><topic>Moxifloxacin (MOX)</topic><topic>傅里叶变换离子回旋共振质谱</topic><topic>分离</topic><topic>性能</topic><topic>杂质分布</topic><topic>液相色谱</topic><topic>紫外检测器</topic><topic>莫西沙星</topic><topic>鉴定</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Cai Sheng</creatorcontrib><creatorcontrib>Jia, Zhi Xin</creatorcontrib><creatorcontrib>Ning, Bao Ming</creatorcontrib><creatorcontrib>Zhang, Jin Lan</creatorcontrib><creatorcontrib>Wu, Song</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>CrossRef</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><jtitle>Chinese chemical letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Cai Sheng</au><au>Jia, Zhi Xin</au><au>Ning, Bao Ming</au><au>Zhang, Jin Lan</au><au>Wu, Song</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Separation and identification of moxifloxacin impurities in drug substance by high-performance liquid chromatography coupled with ultraviolet detection and Fourier transform ion cyclotron resonance mass spectrometry</atitle><jtitle>Chinese chemical letters</jtitle><addtitle>Chinese Chemical Letters</addtitle><date>2012-10-01</date><risdate>2012</risdate><volume>23</volume><issue>10</issue><spage>1185</spage><epage>1188</epage><pages>1185-1188</pages><issn>1001-8417</issn><eissn>1878-5964</eissn><abstract>In this paper, a high-performance liquid chromatography coupled with ultraviolet detection and Fourier transform-ion cyclotron resonance mass spectrometry （HPLC-UV/FrICRMS） method was described for the investigation of impurity profile in moxifloxacin （MOX） drug substance and chemical reference substance. 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| ispartof | Chinese chemical letters, 2012-10, Vol.23 (10), p.1185-1188 |
| issn | 1001-8417 1878-5964 |
| language | eng |
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| source | Elsevier ScienceDirect Journals Complete; Alma/SFX Local Collection |
| subjects | High-performance liquid chromatography coupled with ultraviolet detection and Fourier transform-ion cyclotron resonance mass spectrometry (HPLC–UV/FTICRMS) Impurity profile Moxifloxacin (MOX) 傅里叶变换离子回旋共振质谱 分离 性能 杂质分布 液相色谱 紫外检测器 莫西沙星 鉴定 |
| title | Separation and identification of moxifloxacin impurities in drug substance by high-performance liquid chromatography coupled with ultraviolet detection and Fourier transform ion cyclotron resonance mass spectrometry |
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