Separation and identification of moxifloxacin impurities in drug substance by high-performance liquid chromatography coupled with ultraviolet detection and Fourier transform ion cyclotron resonance mass spectrometry

In this paper, a high-performance liquid chromatography coupled with ultraviolet detection and Fourier transform-ion cyclotron resonance mass spectrometry (HPLC-UV/FrICRMS) method was described for the investigation of impurity profile in moxifloxacin (MOX) drug substance and chemical reference subs...

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Veröffentlicht in:Chinese chemical letters 2012-10, Vol.23 (10), p.1185-1188
Hauptverfasser: Wu, Cai Sheng, Jia, Zhi Xin, Ning, Bao Ming, Zhang, Jin Lan, Wu, Song
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Sprache:eng
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Zusammenfassung:In this paper, a high-performance liquid chromatography coupled with ultraviolet detection and Fourier transform-ion cyclotron resonance mass spectrometry (HPLC-UV/FrICRMS) method was described for the investigation of impurity profile in moxifloxacin (MOX) drug substance and chemical reference substance. Ten impurities were detected by HPLC-UV, while eight impurities were identified by using the high accurate molecular mass combined with multiple-stage mass spectrometric data and fragmentation rules. In addition, to our knowledge, five impurities were founded for the first time in MOX drug substance.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2012.09.001