One-pot five-component synthesis of highly functionalized piperidines using oxalic acid dihydrate as a homogenous catalyst
An efficient green protocol is described for the preparation of highly functionalized piperidines via a one-pot five-component reaction between aromatic aldehydes,anilines andβ-ketoesters in the presence of oxalic acid dihydrate as catalyst in ethanol at ambient temperature.The structure as well as...
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| Veröffentlicht in: | Chinese chemical letters 2012-05, Vol.23 (5), p.569-572 |
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| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | An efficient green protocol is described for the preparation of highly functionalized piperidines via a one-pot five-component reaction between aromatic aldehydes,anilines andβ-ketoesters in the presence of oxalic acid dihydrate as catalyst in ethanol at ambient temperature.The structure as well as the relative stereochemistry of these compounds was confirmed by single X-ray crystallographic analysis. |
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| ISSN: | 1001-8417 1878-5964 |
| DOI: | 10.1016/j.cclet.2012.03.008 |