Un-catalyzed tandem Knoevenagel–Michael reaction for the synthesis of 4,4′-(arylmethylene)bis( 1H-pyrazol-5-ols) in aqueous medium

Un-catalyzed tandem Knoevenagel–Michael reaction for the synthesis of 4,4′-(arylmethylene)bis( 1H-pyrazol-5-ols) in aqueous medium

An environmentally benign un-catalyzed one-pot synthesis of 4,4′-(arylmethylene)bis( 1H-pyrazol-5-ols) has been reported via tandem Knoevenagel–Michael reaction of aldehydes with two equivalents of 3-methyl-1-phenyl-1 H-pyrazol-5(4 H)-one in aqueous medium.

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Veröffentlicht in:Chinese chemical letters 2011-12, Vol.22 (12), p.1415-1418
Hauptverfasser: Tale, Nilesh P., Tiwari, Girdharilal B., Karade, Nandkishor N.
Format: Artikel
Sprache:eng
Schlagworte:
3-Methyl-1-phenyl- 1H-pyrazol-5( 4H)-one
Aldehydes
Aqueous medium
Knoevenagel reaction
Michael addition
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Zusammenfassung:An environmentally benign un-catalyzed one-pot synthesis of 4,4′-(arylmethylene)bis( 1H-pyrazol-5-ols) has been reported via tandem Knoevenagel–Michael reaction of aldehydes with two equivalents of 3-methyl-1-phenyl-1 H-pyrazol-5(4 H)-one in aqueous medium.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2011.09.004