Preparation of 4-and 6-desphenyl analogues of(-)-clausenamide and alternative synthesis of(+)-epi-clausenamide

4- and 6-desphenyl analogues of(-)-clausenamide,6 and 7,were prepared in optical active form from commercially available D-pyroglutamic acid and the known racemic pyrrolidinone 13,respectively.In order to confirm the absolute stereochemistry of(+)-and (-)-7,intermediate 19b was transferred into the(...

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Veröffentlicht in:Chinese chemical letters 2011-11, Vol.22 (11), p.1261-1264
Hauptverfasser: Xue, Jian Jun, Zhou, Yu Mei, Yu, Xiao Ming
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Sprache:eng
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Zusammenfassung:4- and 6-desphenyl analogues of(-)-clausenamide,6 and 7,were prepared in optical active form from commercially available D-pyroglutamic acid and the known racemic pyrrolidinone 13,respectively.In order to confirm the absolute stereochemistry of(+)-and (-)-7,intermediate 19b was transferred into the(+)-epi-clausenamide 8.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2011.07.002