Preparation of 4-and 6-desphenyl analogues of(-)-clausenamide and alternative synthesis of(+)-epi-clausenamide
4- and 6-desphenyl analogues of(-)-clausenamide,6 and 7,were prepared in optical active form from commercially available D-pyroglutamic acid and the known racemic pyrrolidinone 13,respectively.In order to confirm the absolute stereochemistry of(+)-and (-)-7,intermediate 19b was transferred into the(...
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Veröffentlicht in: | Chinese chemical letters 2011-11, Vol.22 (11), p.1261-1264 |
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Hauptverfasser: | , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | 4- and 6-desphenyl analogues of(-)-clausenamide,6 and 7,were prepared in optical active form from commercially available D-pyroglutamic acid and the known racemic pyrrolidinone 13,respectively.In order to confirm the absolute stereochemistry of(+)-and (-)-7,intermediate 19b was transferred into the(+)-epi-clausenamide 8. |
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ISSN: | 1001-8417 1878-5964 |
DOI: | 10.1016/j.cclet.2011.07.002 |