Synthesis of new pyrimidine nucleoside derivatives with nitric oxide donors for antiviral activity

Synthesis of new pyrimidine nucleoside derivatives with nitric oxide donors for antiviral activity

New pyrimidine nucleoside derivatives with nitric oxide（NO） donor were systematically synthesized.The antivirus activities of these nucleoside analogues against vesicular stomatitis virus（VSV） in Wish cell were evaluated.It was demonstrated that most of compounds had stronger antiviral acitivity tha...

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Veröffentlicht in:Chinese chemical letters 2011-08, Vol.22 (8), p.899-902
Hauptverfasser: Shi, Jing Bo, Xu, Song, Wang, Ya Ping, Li, Jing Jing, Yao, Qi Zheng
Format: Artikel
Sprache:eng
Schlagworte:
Antivirus
Furoxans
NO-donor
Oximes
Pyrimidine nucleoside
Synthesis
一氧化氮供体
合成
嘧啶
抗病毒活性
核苷类似物
核苷衍生物
水泡性口炎病毒
阿昔洛韦
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Zusammenfassung:New pyrimidine nucleoside derivatives with nitric oxide（NO） donor were systematically synthesized.The antivirus activities of these nucleoside analogues against vesicular stomatitis virus（VSV） in Wish cell were evaluated.It was demonstrated that most of compounds had stronger antiviral acitivity than acyclovir,while their toxicities were similar or lower to acyclovir.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2011.01.010