Design,synthesis and biological evaluation of 1,4-dihydrothieno[3′,2′：5,6]thiopyrano[4,3-c]pyrazole-3-carboxylic amide derivatives as potential estrogen receptor antagonists

Design,synthesis and biological evaluation of 1,4-dihydrothieno[3′,2′：5,6]thiopyrano[4,3-c]pyrazole-3-carboxylic amide derivatives as potential estrogen receptor antagonists

The estrogen receptor is a target for therapeutic agents for hormone replacement in menopausal women,osteoporosis, reproductive cancers such as breast cancer,uterine cancer and prostate cancer.1,4-Dihydrothieno[3＇,2＇：5,6]thiopyrano[4,3- c]pyrazole-3-carboxylic amide derivatives were designed,synthes...

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Veröffentlicht in:Chinese chemical letters 2011-03, Vol.22 (3), p.256-259
Hauptverfasser: Sun, Rui, Song, Jing, Liu, Si Jie, Zhao, Hui, Yan, Chun Li, Zhang, Ai Jun, Koirala, Diwa, Li, Da Wei, Hu, Chun
Format: Artikel
Sprache:eng
Schlagworte:
Biological activity
Estrogen receptor antagonists
Piperazine
Pyrazole
Synthesis
Thiophene
Thiopyran
受体拮抗剂
酰胺衍生物
雌激素受体
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container_end_page 259
container_issue 3
container_start_page 256
container_title Chinese chemical letters
container_volume 22
creator Sun, Rui
Song, Jing
Liu, Si Jie
Zhao, Hui
Yan, Chun Li
Zhang, Ai Jun
Koirala, Diwa
Li, Da Wei
Hu, Chun
description The estrogen receptor is a target for therapeutic agents for hormone replacement in menopausal women,osteoporosis, reproductive cancers such as breast cancer,uterine cancer and prostate cancer.1,4-Dihydrothieno[3＇,2＇：5,6]thiopyrano[4,3- c]pyrazole-3-carboxylic amide derivatives were designed,synthesized and biological evaluated as potential estrogen receptor antagonists.
doi_str_mv 10.1016/j.cclet.2010.10.029
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source Elsevier ScienceDirect Journals; Alma/SFX Local Collection
subjects Biological activity
Estrogen receptor antagonists
Piperazine
Pyrazole
Synthesis
Thiophene
Thiopyran
受体拮抗剂
酰胺衍生物
雌激素受体
title Design,synthesis and biological evaluation of 1,4-dihydrothieno[3′,2′：5,6]thiopyrano[4,3-c]pyrazole-3-carboxylic amide derivatives as potential estrogen receptor antagonists
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