Design,synthesis and biological evaluation of 1,4-dihydrothieno[3′,2′：5,6]thiopyrano[4,3-c]pyrazole-3-carboxylic amide derivatives as potential estrogen receptor antagonists

The estrogen receptor is a target for therapeutic agents for hormone replacement in menopausal women,osteoporosis, reproductive cancers such as breast cancer,uterine cancer and prostate cancer.1,4-Dihydrothieno[3＇,2＇：5,6]thiopyrano[4,3- c]pyrazole-3-carboxylic amide derivatives were designed,synthes...

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Veröffentlicht in:	Chinese chemical letters 2011-03, Vol.22 (3), p.256-259
Hauptverfasser:	Sun, Rui, Song, Jing, Liu, Si Jie, Zhao, Hui, Yan, Chun Li, Zhang, Ai Jun, Koirala, Diwa, Li, Da Wei, Hu, Chun
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological activity Estrogen receptor antagonists Piperazine Pyrazole Synthesis Thiophene Thiopyran 受体拮抗剂酰胺衍生物雌激素受体
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Zusammenfassung:	The estrogen receptor is a target for therapeutic agents for hormone replacement in menopausal women,osteoporosis, reproductive cancers such as breast cancer,uterine cancer and prostate cancer.1,4-Dihydrothieno[3＇,2＇：5,6]thiopyrano[4,3- c]pyrazole-3-carboxylic amide derivatives were designed,synthesized and biological evaluated as potential estrogen receptor antagonists.
ISSN:	1001-8417 1878-5964
DOI:	10.1016/j.cclet.2010.10.029