The convenient synthesis of 4-arylmethylidene-4,5- dihydro-3-phenylisoxazol-5-ones

4-Arylmethylidene-4,5-dihydro-3-phenylisoxazol-5-ones were synthesized by the convenient three-component reaction of ethyl benzoylacetate, hydroxylamine and aromatic aldehydes in the presence of pyridine. The target compounds were also obtained by the reaction between 3-phenylisoxazol-5-one and arom...

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Veröffentlicht in:Chinese chemical letters 2011-02, Vol.22 (2), p.151-154
Hauptverfasser: Ablajan, Keyume, Xiamuxi, Hainimu
Format: Artikel
Sprache:eng
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Zusammenfassung:4-Arylmethylidene-4,5-dihydro-3-phenylisoxazol-5-ones were synthesized by the convenient three-component reaction of ethyl benzoylacetate, hydroxylamine and aromatic aldehydes in the presence of pyridine. The target compounds were also obtained by the reaction between 3-phenylisoxazol-5-one and aromatic aldehydes at 105 °C under solvent free condition. Yields of products depended considerably on the aldehyde used.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2010.09.023