Synthesis of novel analogues of zanamivir as neuraminidase inhibitors
A versatile synthesis of novel zanamivir analogues modified at C-4 and C-8 positions was described.The formation of amides from the acid with corresponding amines,followed by click chemistry generated the triazole substituted compounds as novel analogues of neuraminidase inhibitors in good yields.
Gespeichert in:
| Veröffentlicht in: | Chinese chemical letters 2010-11, Vol.21 (11), p.1338-1341 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Zusammenfassung: | A versatile synthesis of novel zanamivir analogues modified at C-4 and C-8 positions was described.The formation of amides from the acid with corresponding amines,followed by click chemistry generated the triazole substituted compounds as novel analogues of neuraminidase inhibitors in good yields. |
|---|---|
| ISSN: | 1001-8417 1878-5964 |
| DOI: | 10.1016/j.cclet.2010.06.021 |