Synthesis of novel D-seco-taxoids derived from 1-deoxybaccatin
New D-seco-taxoids were synthesized from 1-deoxybaccatinⅥand their structures were confirmed by 1H NMR,13C NMR, ESIMS and X-ray crystallography.The key step of the synthesis involved the opening of the oxetane ring under acid and basic conditions in order to obtain new multidrug resistance（MDR） reve...
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| Veröffentlicht in: | Chinese chemical letters 2010, Vol.21 (11), p.1273-1276 |
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| Format: | Artikel |
| Sprache: | eng |
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| Online-Zugang: | Volltext |
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| Zusammenfassung: | New D-seco-taxoids were synthesized from 1-deoxybaccatinⅥand their structures were confirmed by 1H NMR,13C NMR, ESIMS and X-ray crystallography.The key step of the synthesis involved the opening of the oxetane ring under acid and basic conditions in order to obtain new multidrug resistance（MDR） reversal agents and new synthetic precursors of paclitaxel analogues. |
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| ISSN: | 1001-8417 1878-5964 |
| DOI: | 10.1016/j.cclet.2010.07.001 |