Synthesis and antitumor activities of novel 1,4-substituted phthalazine derivatives

A series of 1,4-substituted phthalazine derivatives were designed and synthesized.All the prepared compounds were screened for their cytotoxic activities against A549.HT-29 and MDA-MB-231 cell lines in vitro.Among them,compounds 7a-7h showed excellent selectivity for MDA-MB-231 cell line with IC50 v...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Chinese chemical letters 2010-09, Vol.21 (9), p.1071-1074
Hauptverfasser:	Zhang, Shu Lan, Liu, Ya Jing, Zhao, Yan Fang, Guo, Qiu Ting, Gong, Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	1,4-Substituted phthalazine Cytotoxicity IC50 MDA Synthesis 化合物抗肿瘤活性细胞株细胞毒活性衍生物
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A series of 1,4-substituted phthalazine derivatives were designed and synthesized.All the prepared compounds were screened for their cytotoxic activities against A549.HT-29 and MDA-MB-231 cell lines in vitro.Among them,compounds 7a-7h showed excellent selectivity for MDA-MB-231 cell line with IC50 values from 1 nmol/L to 0.92μmol/L.A preliminary SAR study of these derivatives was performed.
ISSN:	1001-8417 1878-5964
DOI:	10.1016/j.cclet.2010.04.004